The Long-Term Effects of Mushrooms

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Our comprehensive guide on the long-term effects of shrooms will provide you with valuable insights and detailed information that will help you understand the potential consequences of using psychedelic mushrooms over an extended period. From the physiological to the psychological effects, we will delve into the intricacies of shroom consumption and its impact on long-term well-being.

Typically hallucinogenic drugs aren’t considered to be as habit-forming as other classifications of recreation drugs like depressants and stimulants.  However, hallucinogens like LSD, DMT, and Magic Mushrooms are controlled substances that can lead to short-term and long-term adverse effects.

Understanding Shrooms

Shrooms, also known as magic mushrooms, refers to a group of fungi that contain psilocybin, a naturally occurring psychedelic compound. These mushrooms are commonly found in various regions across the globe and have been used for centuries for their mind-altering properties. When ingested, psilocybin is converted into psilocin, which interacts with serotonin receptors in the brain, leading to hallucinations, altered perception, and changes in consciousness.

Short-Term Effects vs. Long-Term Effects

Shrooms are renowned for their short-term effects, which typically include euphoria, visual and auditory hallucinations, intensified emotions, altered sense of time, and spiritual experiences. However, our focus here lies on the long-term effects that individuals may experience following repeated or prolonged shroom use.

The Long-Term Physiological Effects of Mushrooms

It is worth highlighting that the risks associated with psychedelic drugs, including psilocybin mushrooms, are mostly psychological rather than physical. Physically, psilocybin mushrooms are considered one of the least toxic drugs known. Lethal doses have been determined in experiments using animal models, but recorded cases of death solely attributed to typical doses of psilocybin mushrooms in humans are extremely rare. 

The physical effects of psilocybin mushrooms are generally minor and can vary from person to person. Common short-term reactions such as dilated pupils, elevated blood pressure, and increased heart rate are usually mild and considered side effects of emotional intensification. Other reported symptoms like nausea, increased perspiration, numbing, and tremors can sometimes make psychological symptoms like anxiety, panic attacks, paranoia, and mood swings appear more pronounced.

The following are some potential psychological side-effects of prolonged mushroom use:

Potential Impact on Brain Chemistry

Long-term shroom use has been associated with potential alterations in brain chemistry. Studies suggest that regular consumption of psilocybin can affect the serotonin system, which plays a crucial role in regulating mood, emotions, and cognitive functions. While more research is needed to fully understand the extent of these changes, it is important to consider the potential implications on long-term mental health.

Hallucinogen Persisting Perception Disorder (HPPD)

One of the recognized long-term effects of shroom use is the development of a condition known as Hallucinogen Persisting Perception Disorder (HPPD). HPPD involves perceptual changes that can persist for weeks or even months following the use of psilocybin and other psychedelics. Although relatively rare, individuals with HPPD may experience recurring visual disturbances, such as seeing trails, halos around objects, or geometric patterns, even when not under the influence of shrooms.

It’s important to note that Hallucinogen Persisting Perception Disorder (HPPD), sometimes mistakenly referred to as “flashbacks,” is a condition unique to psychedelics, including psilocybin. It involves perceptual changes that can last for weeks or even months following the use of such drugs. Although the exact prevalence of HPPD is unknown, it is considered relatively rare, and no physical changes or neurological damage have been associated with its cause.


Another phenomenon associated with long-term shroom use is the occurrence of flashbacks. These experiences involve the sudden reoccurrence of intense sensory perceptions or emotions, often associated with past psychedelic experiences. While flashbacks can be distressing and disruptive, it’s important to note that they are relatively rare and not experienced by everyone.

Long-term physical effects directly attributed to the pharmacology of psilocybin mushrooms are rare, and research suggests that they may also be influenced by underlying psychological disorders.

Comprehensive reviews of thousands of sessions using psilocybin and other psychedelics in legal clinical research settings during the 1950s and 60s consistently found extremely low incidences of acute and chronic problems among individuals without pre-existing severe psychopathology. Recent reviews of the clinical literature also suggest that chronic problematic effects, when they do occur, are most often linked to psychological instability present prior to use.

The Long-Term Psychological Effects of Mushrooms

The long-term psychological effects of shrooms encompass a wide range of potential consequences on an individual’s mental well-being. While shrooms have been explored for their potential therapeutic benefits, it is crucial to understand the possible impact on emotional well-being and mental health. These can include impacts on a person’s emotional stability, personality, and the potential for addiction. 

Emotional Well-being and Mental Health

While shrooms have been explored for their potential therapeutic benefits, it is crucial to acknowledge that long-term use may have implications for emotional well-being and mental health. Some individuals may experience increased anxiety, depression, or even symptoms resembling psychosis. It is important to approach shroom use with caution, particularly for those with pre-existing mental health conditions.

Impact on Personality and Behavior

Long-term shroom use can influence an individual’s personality and behavior. Some users report positive changes, such as increased openness, creativity, and a greater sense of spirituality. However, others may experience negative effects, such as heightened impulsivity or difficulties in social functioning. The impact can vary depending on individual differences, dosage, and frequency of use.

Addiction and Dependence

While shrooms are generally considered to have a low potential for addiction compared to substances like opioids or stimulants, psychological dependence on the psychedelic experience can develop. Individuals may develop a compulsion to use shrooms to recreate desired experiences or cope with emotional challenges. It is crucial to be aware of these addictive tendencies and seek support if necessary.

The Short-Term Effects of Shrooms

The short-term effects of shrooms encompass a range of powerful and often profound experiences. When consumed, psilocybin mushrooms can induce a variety of effects on perception, cognition, and emotions. These effects are typically temporary and can vary from person to person. These fascinating and sometimes intense short-term effects can include euphoria and altered perception as well as visual and auditory hallucinations.

Euphoria and Altered Perception

One of the most notable short-term effects of shrooms is a sense of euphoria and intense emotional experiences. Users often report feelings of joy, happiness, and interconnectedness with their surroundings. Additionally, psilocybin can induce altered perception, resulting in vivid and distorted sensory experiences. Colors may appear more vibrant, and shapes and patterns may seem distorted or morphing.

Visual and Auditory Hallucinations

Shrooms are known for their ability to produce visual and auditory hallucinations. Users may see geometric patterns, objects appearing to breathe or pulsate or experience enhanced visual acuity. Auditory hallucinations can manifest as intensified sounds, music taking on a richer quality, or hearing voices or sounds that aren’t present.

Altered Sense of Time and Space

Under the influence of psilocybin, users often report a distorted sense of time and space. Minutes may feel like hours, and the concept of time may become fluid and subjective. Users may also feel a sense of connectedness with the universe and an expanded perception of their place within it.

Spiritual and Mystical Experiences

Many individuals who use shrooms describe profound spiritual or mystical experiences. These experiences can involve a deep sense of unity with the universe, a connection to a higher power, or a feeling of transcendence beyond the limitations of the physical self. Such experiences can have a profound impact on an individual’s worldview and sense of spirituality.

Increased Emotional Intensity

Emotional experiences on psilocybin mushrooms can be heightened and intensified. Users may undergo intense emotional states, ranging from euphoria and bliss to sadness or anxiety. The emotional release and exploration facilitated by shrooms can provide individuals with insights into their emotions and help them process unresolved issues or trauma.

Physical Sensations and Bodily Effects

Alongside the psychological effects, shrooms can induce various physical sensations. These can include changes in body temperature, tactile enhancements, and altered bodily perceptions. Users may also experience physical effects such as dilated pupils, increased heart rate, and changes in blood pressure. It’s important to note that these physical effects are generally temporary and subside as the effects of psilocybin wear off.

Please remember that the short-term effects of shrooms can vary among individuals, and the intensity and nature of the experience depend on factors such as dosage, set, and setting.

Risk Mitigation and Harm Reduction Strategies

Understanding the potential long-term effects of shrooms is essential for making informed decisions. If you choose to engage in psychedelic experiences involving magic mushrooms, here are some harm-reduction strategies to consider:

Responsible Use

Ensure that you are well informed about the proper dosage, effects, and potential risks associated with shrooms. Start with low doses and gradually increase if necessary, always in a safe and comfortable environment, preferably with a trusted person present.

Set and Setting

Create a conducive setting for your psychedelic experience. Choose a comfortable, familiar, and safe space where you feel secure. Surround yourself with positive influences, such as supportive friends or calming music, to enhance the overall experience.

Integration and Support

After the experience, take time to reflect on and integrate the insights gained. It can be beneficial to discuss your experience with a therapist or participate in support groups where you can share and learn from others’ experiences.

Mindful Monitoring

Regularly assess your emotional well-being and mental health. If you notice any concerning changes or symptoms, seek professional help. A qualified healthcare provider can offer guidance and support tailored to your specific needs.

Medicinal and Therapeutic Effects of Mushrooms

There is strong evidence suggesting that carefully monitored and controlled use of psilocybin, the active compound in mushrooms may have beneficial effects. In the mid-20th century, fully legal and well-funded research programs found that psilocybin could be valuable in treating various psychiatric disorders, aiding personal and spiritual development, and enhancing creativity. However, after psilocybin was banned in 1970, clinical research evaluating the medical safety and efficacy of psychedelics came to a halt until the late 1990s and early 2000s.

Today, numerous studies are underway to assess the medical safety and efficacy of psychedelics, including psilocybin. While early research often did not meet today’s standards due to the absence of placebo control groups or double-blinding procedures, their promising findings have led to a resurgence of more rigorous research on the potential benefits of psychedelics.

Research has shown the potential benefits of psychedelics, including psilocybin, as a treatment for various conditions. These include cluster headaches, anxiety, addiction to alcohol and other drugs, depression, and obsessive-compulsive disorder. Furthermore, neuroimaging experiments have contributed to a better understanding of how psilocybin affects the brain.

Unfortunately, due to the complex and expensive approval process for research involving Schedule I drugs, as well as the influence of the war on drugs, studies evaluating the beneficial uses of psilocybin often lack funding from academic or government institutions. Instead, nonprofit organizations like the Multidisciplinary Association for Psychedelic Studies, the Beckley Foundation, and the Heffter Research Institute play a significant role in supporting and conducting research in this field.

The ongoing research aims to provide a deeper understanding of the therapeutic potential of mushrooms and expand their use as a viable treatment option. Although challenges exist, the growing body of evidence supports the notion that mushrooms, when used in controlled and supervised settings, have the potential to offer significant benefits in various therapeutic contexts.

It is crucial to note that individuals should not attempt self-medication with mushrooms or psilocybin without proper guidance and supervision from trained professionals. Only through rigorous research and responsible clinical practice can the true potential of mushrooms as a therapeutic tool be fully understood and realized.

For more information on the Pros, Cons, and Unknowns of using psilocybin mushrooms to treat mental health issues, read our article on Microdosing Mushrooms.

Considering the Long-Term Effects of Mushrooms

The long-term effects of shrooms encompass both physiological and psychological dimensions. While some individuals may benefit from their use, it is important to approach shrooms with caution, considering the potential risks and impact they may have on your overall well-being. By understanding the potential consequences and implementing harm reduction strategies, you can make informed decisions and mitigate potential harm associated with long-term shroom use.

This article was created to serve as a comprehensive guide to educate and inform readers about the long-term effects of shrooms. It is crucial to conduct further research and consult with professionals for personalized advice and guidance based on your specific circumstances.

It is worth noting that the field of psychedelic research is rapidly evolving, and new studies are continually being conducted to enhance our understanding of the long-term effects of shrooms. Stay informed about the latest scientific advancements and updates in this field to make well-informed decisions regarding your psychedelic experiences.

In summary, shrooms have the potential to induce both short-term and long-term effects. While the physical risks are relatively low, it is the psychological impact that requires careful consideration. The long-term effects may vary among individuals, and factors such as pre-existing mental health conditions and responsible use play crucial roles.

By staying informed, adopting harm reduction strategies, and seeking professional guidance when needed, individuals can minimize potential risks and maximize the potential benefits of their shroom experiences. Remember to prioritize your well-being and approach psychedelic use with respect, caution, and an understanding of your own unique circumstances.

Please note that this article provides a comprehensive overview of the long-term effects of shrooms based on current knowledge and research. It is essential to stay updated on new findings and consult authoritative sources for the most accurate and up-to-date information.

If you or a loved one are struggling with a mental health disorder or substance use disorder, please feel free to reach out to us today.  Healthy Life Recovery is a San Diego Drug and Alcohol Rehab Center that also offers a mental health track for people with a dual diagnosis or mental health issue.


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Dr. Sanajai Thankachen

Medically Reviewed By:

Dr. Sanjai Thankachen

Dr. Sanjai Thankachen graduated from Adichunchanagiri Institute of Medicine in 2000. He completed his residency in psychiatry in 2008 at Creedmoor Psychiatric Center in New York. Dr. Thankachen is currently working with Pacific Neuropsychiatric Specialists in an outpatient practice, as well as working at multiple in-patient psychiatric and medical units bringing his patients the most advanced healthcare treatment in psychiatry. Dr. Thankachen sees patients with an array of disorders, including depression, bipolar illness, schizophrenia, anxiety, and dementia-related problems.

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Sean Leonard Bio Image

Edited for Clinical Accuracy By:

Sean Leonard, Psychiatric Nurse Practitioner

Sean Leonard is a board-certified psychiatric nurse practitioner. He received his master’s degree in adult geriatric primary care nurse practitioner from Walden University and a second postmaster specialty in psychiatry mental health nurse practitioner from Rocky Mountain University. Sean has experience working in various diverse settings, including an outpatient clinic, inpatient detox and rehab, psychiatric emergency, and dual diagnosis programs. His specialty areas include substance abuse, depression, anxiety, mood disorders, PTSD, ADHD, and OCD.

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